Sitemap
Trazodone Guide
- What Is Trazodone? An Overview
- How Trazodone Works in the Brain and Body
- Trazodone for Depression: What to Expect
- Trazodone for Insomnia: The Off-Label Use Explained
- Trazodone for Anxiety
- Trazodone Dosage Guide
- Understanding Trazodone's Boxed Warning
- Trazodone Side Effects: A Complete Overview
- Trazodone Drug Interactions: A Complete Overview
- Trazodone and Pregnancy
- Trazodone and Breastfeeding
- Trazodone for Older Adults
- Trazodone in Children and Teens
- Trazodone Overdose: Signs and What to Do
- Trazodone vs. Zolpidem (Ambien): Comparing Sleep Options
- Trazodone vs. Melatonin
- Trazodone vs. Mirtazapine
- Trazodone vs. Doxepin for Sleep
- The History of Trazodone
- Generic Trazodone: Manufacturers and Availability
- Trazodone Cost and Insurance Coverage
- How to Store Trazodone Safely
- What to Do About a Missed Dose
- Trazodone Half-Life and How Long It Stays in Your System
- How to Taper Off Trazodone
- Trazodone as Augmentation Therapy for Depression
- Trazodone for PTSD-Related Nightmares
- Trazodone and Driving Safety
- Trazodone Before Surgery
- Immediate-Release vs. Extended-Release Trazodone
Side-Effect Library
- Drowsiness and sedation
- Dizziness and lightheadedness
- Dry mouth
- Headache
- Nausea and vomiting
- Blurred vision
- Constipation
- Fatigue and tiredness
- Nasal congestion (stuffy nose)
- Weight changes
- Diarrhea
- Swelling (edema)
- Tremor (shakiness)
- Confusion
- Memory and concentration problems
- Ringing in the ears (tinnitus)
- Decreased libido
- Muscle aches and pains
- Changes in taste
- Vivid or unusual dreams
- Significant drops in blood pressure on standing
- Unusual bruising or bleeding
- Triggering mania or hypomania
- Severe allergic reaction
- Changes in blood cell counts
- Priapism (prolonged erection)
- Serotonin syndrome
- Irregular heartbeat or fainting (QT prolongation)
- Low blood sodium (hyponatremia)
- Worsening depression or suicidal thoughts
- Seizures
- Severe breathing problems
Interaction Library
- Trazodone and MAOIs (monoamine oxidase inhibitors)
- Trazodone and SSRIs
- Trazodone and SNRIs
- Trazodone and triptans (migraine medications)
- Trazodone and tramadol
- Trazodone and linezolid
- Trazodone and methylene blue
- Trazodone and lithium
- Trazodone and buspirone
- Trazodone and mirtazapine
- Trazodone and bupropion
- Trazodone and dextromethorphan (DXM)
- Trazodone and St. John's Wort
- Trazodone and tryptophan supplements
- Trazodone and 5-HTP
- Trazodone and carbamazepine
- Trazodone and azole antifungals
- Trazodone and macrolide antibiotics
- Trazodone and ritonavir (HIV protease inhibitors)
- Trazodone and rifampin
- Trazodone and phenobarbital
- Trazodone and grapefruit juice
- Trazodone and benzodiazepines
- Trazodone and opioid pain medications
- Trazodone and zolpidem (or other prescription sleep aids)
- Trazodone and alcohol
- Trazodone and cannabis
- Trazodone and diphenhydramine (Benadryl and similar OTC sleep aids)
- Trazodone and melatonin
- Trazodone and digoxin
- Trazodone and phenytoin
- Trazodone and warfarin
- Trazodone and NSAIDs
- Trazodone and aspirin
- Trazodone and clopidogrel (or other antiplatelet medications)
- Trazodone and other blood pressure medications
- Trazodone and QT-prolonging antipsychotic medications
- Trazodone and QT-prolonging antibiotics
- Trazodone with a personal or family history of heart rhythm problems
- Trazodone and general anesthesia (surgery)
- Trazodone with sickle cell disease, multiple myeloma, or leukemia
Questions & Answers
- How long does it take for trazodone to start working?
- What is the usual starting dose of trazodone?
- Should I take trazodone with food?
- What happens if I miss a dose of trazodone?
- Can I split or crush trazodone tablets?
- What is the maximum dose of trazodone?
- Can trazodone be taken once daily instead of multiple times a day?
- Can I drink alcohol while taking trazodone?
- Is trazodone safe to take with an SSRI like sertraline or fluoxetine?
- Can I take ibuprofen or Tylenol with trazodone?
- Is it safe to take melatonin with trazodone?
- What is serotonin syndrome and how would I know if I had it?
- Can trazodone cause a false positive on a drug test?
- Is trazodone a controlled substance?
- Can I take trazodone if I have high blood pressure?
- Does trazodone affect heart rhythm?
- Does trazodone cause weight gain?
- Why does trazodone make me so drowsy?
- Can trazodone cause vivid dreams or nightmares?
- How long do trazodone side effects last?
- What should I do if I get a headache from trazodone?
- Can trazodone cause sexual side effects?
- Is trazodone FDA-approved for insomnia?
- Is low-dose trazodone for sleep addictive?
- How does trazodone compare to melatonin for sleep?
- How does trazodone compare to zolpidem (Ambien) for sleep?
- Will I build tolerance to trazodone for sleep over time?
- How do I stop taking trazodone safely?
- What withdrawal symptoms can happen if I stop trazodone suddenly?
- How long does trazodone withdrawal last?
- Can I just stop trazodone if I only took it for a few nights for sleep?
- Is trazodone safe during pregnancy?
- Can I take trazodone while breastfeeding?
- Is trazodone safe for older adults?
- Is trazodone approved for children or teenagers?
- Does trazodone need to be adjusted for kidney or liver problems?
- How should I store trazodone?
- How should I dispose of unused trazodone?
- Is generic trazodone the same as brand-name Desyrel?
- Why does my trazodone prescription come with a Medication Guide?
- Can I drive after taking trazodone?
- Does insurance typically cover trazodone?
Glossary
- SARI (Serotonin Antagonist and Reuptake Inhibitor)
- Mechanism of action
- Active metabolite
- Half-life
- Bioavailability
- CYP3A4
- Serotonin syndrome
- Priapism
- Orthostatic hypotension
- QT prolongation
- Boxed warning
- Off-label use
- Discontinuation syndrome
- Major depressive disorder (MDD)
- Titration
- Sedative-hypnotic
- Anticholinergic effects
- Extended-release (ER) formulation
- Immediate-release (IR) tablet
- Augmentation therapy
- Washout period
- SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion)
- Therapeutic index
- PRN dosing
- Generic drug
- Controlled substance schedule
- First-pass metabolism
- Medication guide
- Angle-closure glaucoma risk
- Drug interaction
Research & Updates
- What the Research Says About Trazodone for Insomnia
- Trazodone and Falls Risk in Older Adults: What the Evidence Shows
- Trazodone's Cardiac Safety Profile: What Postmarketing Data Shows
- Comparing Antidepressant Discontinuation Symptoms Across Drug Classes
- Trazodone Prescribing Trends in the United States
- Research on Trazodone for PTSD-Related Sleep Disturbance
- Understanding the Antidepressant Boxed Warning: What the Data Actually Showed
- Priapism Risk with Trazodone: What Case Report Data Tells Us
- Trazodone Augmentation Studies for Depression
- Serotonin Syndrome Case Reports Involving Trazodone: Patterns and Lessons
- Trazodone Use in Pregnancy: A Review of Observational Data
- How Trazodone's Off-Label Use Became So Widespread: A Look at Prescribing Data
Printables
- Questions to Ask Before Starting Trazodone
- Trazodone Dosing Schedule Tracker
- Side Effect Symptom Diary
- Sleep Hygiene Checklist
- Medication Interaction Checklist for Trazodone
- Emergency Warning Signs Wallet Card
- Trazodone vs. Other Sleep Aids: Comparison Chart
- Trazodone Tapering Schedule Template
- Pharmacist Consultation Checklist
- New Prescription Checklist