Warfarin requires regular blood monitoring (INR) because so many medications and even foods can shift its effect. Trazodone-specific data is limited compared to some other antidepressants, but serotonergic medications in general can affect platelet function, adding a bleeding-risk consideration on top of any INR shifts. Anyone on warfarin starting trazodone should mention it to whoever manages their anticoagulation monitoring.
Trazodone and warfarin
Warfarin's effect can be altered by many medications; while data specific to trazodone is limited, serotonergic drugs generally carry some bleeding-risk consideration with anticoagulants.
Editorially reviewed
Key points
- Warfarin is sensitive to many drug and dietary changes generally
- Serotonergic drugs can affect platelet function independent of INR
- Tell your anticoagulation clinic about any new medication
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.