Certain macrolide antibiotics, particularly clarithromycin and erythromycin, inhibit CYP3A4 and can increase trazodone blood levels during the (usually short) course of antibiotic treatment. This is generally manageable with awareness — mention all current medications when a new antibiotic is prescribed.
Trazodone and macrolide antibiotics
Clarithromycin and erythromycin are CYP3A4 inhibitors that can raise trazodone levels similarly to azole antifungals.
Editorially reviewed
Key points
- Clarithromycin and erythromycin are the main concern in this class
- Effect is usually temporary, matching a short antibiotic course
- Always mention current medications when prescribed a new antibiotic
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.