Reported by a meaningful share of trazodone users, particularly early in treatment, and often reduced by taking the dose with food.
Nausea is a common gastrointestinal side effect across many antidepressants that affect serotonin activity, since serotonin receptors are present throughout the gut. Taking trazodone with food can both reduce nausea and change its absorption profile slightly.
Vomiting is less common than nausea alone but is listed in trazodone's overdose reaction profile as well, so vomiting that is severe, persistent, or accompanied by other symptoms warrants medical attention.
A commonly reported, minor side effect specifically listed in trazodone's FDA labeling.
Read more →Distinct from acute drowsiness, this is a lingering sense of low energy some people notice, especially early in treatment.
Read more →A commonly reported digestive side effect, generally manageable with fiber, fluids, and activity.
Read more →A frequently reported effect linked to trazodone's impact on blood pressure regulation, especially when changing position quickly.
Read more →The Medication Companion lets you log doses, sleep, symptoms, and questions for your prescriber — privately, in your browser, no account required to start.