Trazodone's alpha-1 adrenergic blocking activity already tends to lower blood pressure somewhat, particularly on standing. Combined with medications specifically prescribed to lower blood pressure, the effect can add together, increasing dizziness, lightheadedness, and fall risk — especially in older adults or anyone starting either medication or increasing a dose.
Trazodone and other blood pressure medications
Because trazodone itself can lower blood pressure, combining it with antihypertensive medications can produce an additive drop, increasing dizziness and fall risk.
Editorially reviewed
Key points
- Trazodone itself has some blood-pressure-lowering activity
- Effects can add together with antihypertensive medications
- Extra caution during dose changes for either medication
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.