Low-dose daily aspirin, often taken for heart health, has its own antiplatelet effect. Combined with trazodone's serotonergic activity on platelets, this may modestly increase bruising or bleeding risk for some people. This is generally not a reason to avoid the combination, but it is worth mentioning to your prescriber, particularly if you notice unusual bruising.
Trazodone and aspirin
Like other NSAIDs, aspirin's antiplatelet effect combined with trazodone's serotonergic activity can modestly add to bleeding risk.
Editorially reviewed
Key points
- Relevant mainly for people on regular daily aspirin
- Generally not a reason to avoid the combination outright
- Mention any unusual bruising to your prescriber
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.