Headache is frequently reported in clinical trials of trazodone, as it is with many antidepressants. It often improves after the first few weeks as the body adjusts. Staying hydrated and maintaining regular sleep can help; persistent or severe headache should be discussed with a prescriber.
Headache
A commonly reported, generally mild-to-moderate side effect, particularly in the first weeks of treatment.
Editorially reviewed
Key points
- Common in the first few weeks of treatment
- Often improves with continued use
- Discuss severe or persistent headache with your prescriber
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.