Benzodiazepines like alprazolam, lorazepam, and diazepam are prescribed for anxiety or sleep and, like trazodone, depress central nervous system activity. Combined, the sedative effects add together, increasing drowsiness, impaired coordination, and fall risk — a particular concern for older adults. This combination is sometimes used clinically but requires careful dose management.
Trazodone and benzodiazepines
Both drug classes are CNS depressants, and combining them significantly increases sedation, coordination problems, and fall risk.
Editorially reviewed
Key points
- Additive CNS depression increases fall and coordination risk
- Particular concern for older adults
- Sometimes combined clinically, but requires careful dosing
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.