Evidence on trazodone and cannabis specifically is more limited than for alcohol, but cannabis's general sedating and heart-rate-altering effects mean this combination should be approached cautiously. Some people report increased drowsiness or lightheadedness; effects vary by cannabis product, dose, and route of use. Tell your prescriber about regular cannabis use.
Trazodone and cannabis
Cannabis can add to trazodone's sedating effects and, in some people, affect heart rate and blood pressure in ways that compound trazodone's own cardiovascular effects.
Editorially reviewed
Key points
- Less directly studied than alcohol, but similar caution applies
- Effects vary significantly by product and dose
- Disclose regular use to your prescriber
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.