L-tryptophan is the amino acid the body uses to make serotonin. Taking tryptophan supplements while on trazodone increases the raw material available for serotonin production at the same time trazodone is affecting serotonin receptors and reuptake — a combination that has been linked to serotonin syndrome in case reports.
Trazodone and tryptophan supplements
Tryptophan is a direct serotonin precursor, and supplementing it while taking trazodone can meaningfully raise serotonin syndrome risk.
Editorially reviewed
Key points
- Tryptophan is a direct serotonin precursor
- Linked to serotonin syndrome in case reports when combined
- Discuss any supplement use with your prescriber
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.