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Immediate-Release vs. Extended-Release Trazodone

The practical differences between the two trazodone formulations, and why immediate-release is far more commonly prescribed today.

Editorially reviewed
Key points
  • Immediate-release is far more commonly prescribed today
  • Extended-release aimed for smoother once-daily blood levels
  • Extended-release tablets generally should not be split or crushed

Immediate-release trazodone tablets release their full dose promptly and are typically taken multiple times a day for depression, or once at bedtime for off-label sleep use. An extended-release formulation (branded Oleptro) was designed for smoother, once-daily dosing with fewer peaks and troughs in blood level.

Today, the overwhelming majority of trazodone prescribed in the U.S. is the immediate-release generic tablet. If you're prescribed an extended-release product, it should generally not be split or crushed, since doing so can release the full dose at once rather than gradually.

References

  1. Trazodone: MedlinePlus Drug Information. U.S. National Library of Medicine (MedlinePlus). View source (opens in a new tab) Accessed August 8, 2026
  2. Trazodone Hydrochloride Tablets — FDA Prescribing Information. DailyMed / U.S. Food & Drug Administration. View source (opens in a new tab) Accessed August 8, 2026
Not medical advice. This article is educational and does not replace guidance from your prescriber or pharmacist. If you think you're having a serious reaction, see our emergency resources page.

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