Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, sertraline, paroxetine, escitalopram, and citalopram increase serotonin activity, as does trazodone. This combination is actually common in clinical practice — low-dose trazodone is often added at bedtime specifically to help with SSRI-related sleep disruption — but it should only be done under a prescriber's supervision, with awareness of serotonin syndrome symptoms.
Trazodone and SSRIs
SSRIs and trazodone are both serotonergic, so combining them increases serotonin syndrome risk — though low-dose trazodone is also commonly and intentionally added to an SSRI regimen under medical supervision for sleep.
Editorially reviewed
Key points
- A common, intentional combination under medical supervision
- Still carries a real serotonin syndrome risk if unsupervised
- Know the warning signs of serotonin syndrome either way
Seek urgent care if you notice:
- Agitation, confusion, or hallucinations
- Fast heartbeat, sweating, and diarrhea together
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.