Immunoassay-based drug screens (the rapid tests often used for workplace or clinical screening) are known to occasionally cross-react with unrelated substances, and isolated reports describe this with trazodone on some panels. If a result seems inconsistent with your actual medication use, a confirmatory lab test (like GC-MS) can clarify this, and disclosing your prescribed medications to the testing lab in advance is generally good practice.
Can trazodone cause a false positive on a drug test?
Short answer: There have been isolated reports of trazodone or its metabolites causing false positives on certain immunoassay drug screens, though this is not common or well-established.
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Not medical advice. This answer is general and educational. Your prescriber knows your full history and can give guidance specific to you.