Linezolid is used to treat certain serious bacterial infections, but it also weakly inhibits monoamine oxidase — the same enzyme MAOI antidepressants target. This gives it a similar serotonin syndrome interaction profile to true MAOIs when combined with trazodone. If linezolid is needed, prescribers may need to temporarily hold trazodone or choose an alternative antibiotic.
Trazodone and linezolid
Linezolid is an antibiotic with MAOI-like activity, and combining it with serotonergic antidepressants including trazodone carries a labeled serotonin syndrome warning.
Editorially reviewed
Key points
- Linezolid has weak MAOI-like activity
- Similar risk profile to a true MAOI interaction
- Prescribers may hold trazodone or choose a different antibiotic
Seek urgent care if you notice:
- Fever, agitation, confusion after starting linezolid
- Rapid heartbeat or muscle rigidity
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.