Trazodone undergoes hepatic (liver) metabolism, so significant liver impairment can change how the drug is processed and how long its effects last. Kidney function also plays a role in clearing some byproducts. If you have known liver or kidney disease, make sure your prescriber has this information before starting or adjusting trazodone.
Does trazodone need to be adjusted for kidney or liver problems?
Short answer: Because trazodone is processed by the liver and its byproducts are cleared partly by the kidneys, significant liver or kidney impairment may call for dose adjustment or closer monitoring — this should be individualized by your prescriber.
Editorially reviewed
Not medical advice. This answer is general and educational. Your prescriber knows your full history and can give guidance specific to you.