Alcohol is a central nervous system depressant, just like trazodone's sedating mechanism — combining them produces more sedation and impairment than either alone, along with a greater drop in blood pressure and worse coordination and judgment. Trazodone's prescribing information advises against alcohol use during treatment.
Trazodone and alcohol
Alcohol significantly compounds trazodone's sedative and blood-pressure-lowering effects, and this combination is specifically discouraged in trazodone's prescribing information.
Editorially reviewed
Key points
- Sedative effects add together, not just overlap
- Also worsens blood-pressure-related dizziness
- Specifically advised against in prescribing information
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.