Respiratory arrest is listed among the most severe reactions reported with trazodone overdose, particularly when combined with other CNS-depressing substances.
Respiratory arrest — a complete stop in breathing — is listed in trazodone's prescribing information among the most severe reactions reported in overdose. This risk rises sharply when trazodone is combined with alcohol, opioids, benzodiazepines, or other substances that also suppress breathing and the central nervous system.
Call 911 immediately for any suspected overdose or serious breathing difficulty, and contact Poison Control at 1-800-222-1222 for guidance.
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