Trazodone's Medication Guide describes this as feeling unusually high or irritable, having too much energy, talking rapidly, or not sleeping. This is a recognized risk across antidepressant medications when an underlying bipolar spectrum condition is present but not yet diagnosed.
Triggering mania or hypomania
Like other antidepressants, trazodone can occasionally unmask or trigger manic or hypomanic symptoms, particularly in people with undiagnosed bipolar disorder.
Editorially reviewed
Key points
- A known risk across antidepressant medications generally
- May reveal previously undiagnosed bipolar disorder
- Report sudden mood elevation, rapid speech, or major energy changes
Call your prescriber or seek care if you notice:
- Unusual euphoria or irritability
- Sharply reduced need for sleep
- Racing thoughts or rapid speech
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.