Lithium is sometimes used alongside antidepressants, including trazodone, for augmentation in mood disorders. While this combination is used clinically, case reports describe serotonergic symptoms when lithium is combined with serotonergic antidepressants, so it requires monitoring by the prescribing team.
Trazodone and lithium
Lithium can enhance serotonergic effects and has been reported in combination with trazodone to occasionally contribute to serotonin-related symptoms.
Editorially reviewed
Key points
- Used clinically for augmentation under supervision
- Case reports describe serotonergic symptoms in combination
- Requires monitoring by the prescribing team
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.