Melatonin helps regulate the body's natural sleep-wake signaling and is available without a prescription; its effect is generally milder than trazodone's. Trazodone requires a prescription and produces more pronounced sedation through antihistamine and serotonin receptor activity, which is why it is used for more persistent or difficult insomnia rather than as a first, gentle option.
How does trazodone compare to melatonin for sleep?
Short answer: Melatonin is an over-the-counter hormone supplement with a different, milder mechanism; trazodone is a prescription antidepressant used off-label for sleep, generally considered more sedating.
Editorially reviewed
Not medical advice. This answer is general and educational. Your prescriber knows your full history and can give guidance specific to you.