Bupropion is one of the few widely used antidepressants that is not primarily serotonergic, so this combination carries less serotonin syndrome concern than pairing trazodone with an SSRI or SNRI. It is a fairly common combination in practice — for example, bupropion during the day with low-dose trazodone at night — but should still be managed by a prescriber, since bupropion can lower seizure threshold.
Trazodone and bupropion
Bupropion works on dopamine and norepinephrine rather than serotonin, but the combination with trazodone is common in practice and worth understanding.
Editorially reviewed
Key points
- Lower serotonin syndrome concern than SSRI/SNRI combinations
- A fairly common combination in clinical practice
- Bupropion's seizure-threshold effect is the main separate consideration
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.