Trazodone's FDA labeling specifically lists unusual bruising or bleeding among the serious side effects to watch for. This relates to serotonin's role in platelet function. The risk is generally higher when trazodone is combined with blood thinners, aspirin, or NSAIDs.
Unusual bruising or bleeding
Serotonergic antidepressants, including trazodone, can affect platelet function, occasionally leading to increased bruising or bleeding.
Editorially reviewed
Key points
- Listed specifically in FDA labeling as a serious side effect
- Risk increases when combined with blood thinners or NSAIDs
- Tell your prescriber about any unusual bruising or bleeding
Call your prescriber or seek care if you notice:
- Bruising without a clear cause
- Nosebleeds or bleeding gums more often than usual
- Blood in urine or stool
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.