Azole antifungals such as ketoconazole and itraconazole strongly inhibit CYP3A4, slowing trazodone's breakdown and raising its blood concentration. This can intensify side effects like sedation, dizziness, and low blood pressure. A lower trazodone dose or a different antifungal choice may be appropriate — discuss with your prescriber.
Trazodone and azole antifungals
Strong CYP3A4 inhibitors like ketoconazole and itraconazole can substantially raise trazodone blood levels, increasing the risk of side effects.
Editorially reviewed
Key points
- Strong CYP3A4 inhibitors raise trazodone blood levels
- Can intensify sedation and blood-pressure-related side effects
- A dose adjustment or alternative may be appropriate
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.