These changes are uncommon but have been reported with trazodone. Unexplained fever, frequent infections, or unusual bruising while taking trazodone should prompt a call to your prescriber, who may check blood counts.
Changes in blood cell counts
Rare reports describe changes in white blood cell or platelet counts associated with trazodone, which can affect infection resistance or bleeding risk.
Editorially reviewed
Key points
- Uncommon but documented
- Watch for unexplained fever or frequent infections
Call your prescriber or seek care if you notice:
- Persistent unexplained fever
- Frequent or unusual infections
- Unusual bruising or bleeding
Not medical advice. This page describes general patterns reported for trazodone and does not replace individualized guidance from your prescriber or pharmacist.