SNRIs such as venlafaxine and duloxetine increase both serotonin and norepinephrine activity. Combined with trazodone's own serotonergic activity, the serotonin syndrome risk is comparable to combining trazodone with an SSRI. This combination sometimes occurs intentionally for augmentation, but requires prescriber oversight.
Trazodone and SNRIs
Serotonin-norepinephrine reuptake inhibitors carry a similar serotonin syndrome consideration to SSRIs when combined with trazodone.
Editorially reviewed
Key points
- Similar serotonin syndrome profile to SSRI combinations
- Sometimes used intentionally for depression augmentation
- Requires prescriber oversight either way
Seek urgent care if you notice:
- Agitation, tremor, or muscle twitching
- Fever with rapid heartbeat
Not medical advice. Always tell your prescriber and pharmacist about every medication, supplement, and substance you use so they can check for interactions specific to your situation.