Trazodone Interaction Library
How trazodone interacts with other prescription medications, over-the-counter drugs, supplements, alcohol, and cannabis — each rated by how well-established the evidence is.
Trazodone and other blood pressure medications
Because trazodone itself can lower blood pressure, combining it with antihypertensive medications can produce an additive drop, increasing d…
Read more → Well establishedTrazodone and phenobarbital
Phenobarbital both induces CYP3A4 (lowering trazodone levels over time) and adds direct sedative effects — a combination with two separate i…
Read more → Well establishedTrazodone and phenytoin
Similar to digoxin, case reports describe trazodone increasing phenytoin blood levels, which is relevant because phenytoin also has a narrow…
Read more → Limited evidenceTrazodone and QT-prolonging antibiotics
Certain antibiotics, including some macrolides and fluoroquinolones, also affect the QT interval, adding to trazodone's own documented cardi…
Read more → Limited evidenceTrazodone and QT-prolonging antipsychotic medications
Some antipsychotics also prolong the QT interval, and combining two QT-prolonging medications raises the risk beyond either alone.
Read more → Well establishedTrazodone and rifampin
Rifampin, used to treat tuberculosis and some other infections, is a strong CYP3A4 inducer that can meaningfully reduce trazodone's effectiv…
Read more → Per FDA labelTrazodone and ritonavir (HIV protease inhibitors)
Ritonavir is one of the strongest known CYP3A4 inhibitors and is specifically discussed in trazodone's pharmacokinetic literature for this r…
Read more → Well establishedTrazodone and SNRIs
Serotonin-norepinephrine reuptake inhibitors carry a similar serotonin syndrome consideration to SSRIs when combined with trazodone.
Read more → Well establishedTrazodone and SSRIs
SSRIs and trazodone are both serotonergic, so combining them increases serotonin syndrome risk — though low-dose trazodone is also commonly…
Read more → Well establishedTrazodone and St. John's Wort
This popular herbal supplement is both serotonergic and a CYP3A4 inducer, giving it a double interaction risk with trazodone: serotonin synd…
Read more → Well establishedTrazodone and tramadol
Tramadol has serotonergic activity in addition to its opioid effects, adding both serotonin syndrome and seizure-threshold concerns when com…
Read more → Per FDA labelTrazodone and triptans (migraine medications)
Triptans act directly on serotonin receptors to treat migraines, and combining them with trazodone is specifically flagged as a serotonin sy…
Read more → Limited evidenceTrazodone and tryptophan supplements
Tryptophan is a direct serotonin precursor, and supplementing it while taking trazodone can meaningfully raise serotonin syndrome risk.
Read more → Limited evidenceTrazodone and warfarin
Warfarin's effect can be altered by many medications; while data specific to trazodone is limited, serotonergic drugs generally carry some b…
Read more → Well establishedTrazodone and zolpidem (or other prescription sleep aids)
Combining two sedating sleep medications compounds drowsiness and next-morning impairment risk, and is generally avoided rather than intenti…
Read more → Per FDA labelTrazodone with a personal or family history of heart rhythm problems
A personal or family history of QT prolongation, arrhythmia, or unexplained fainting is directly relevant to trazodone's labeled cardiac ris…
Read more → Per FDA labelTrazodone with sickle cell disease, multiple myeloma, or leukemia
These conditions are specifically named in trazodone's FDA labeling as raising baseline priapism risk, and should be discussed with a prescr…
Read more →Not sure if your combination is covered here?
The Interaction Question Builder walks through your specific medications and generates a printable summary of questions to bring to your pharmacist or prescriber.